Rho Family GTPases and Rho GEFs in Glucose Homeostasis
نویسندگان
چکیده
منابع مشابه
Rho family GTPases.
Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton, although, in addition, they promote a wide...
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Rho RhoA (RHOA) Plasma membrane (PM) and cytosol/ geranylgeranylation (GG), phosphorylation (PH), ubiquitination (Ub)
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Within blood vessels, endothelial cellâ€"cell and cellâ€"matrix adhesions are crucial to preserve barrier function, and these adhesions are tightly controlled during vascular development, angiogenesis, and transendothelial migration of inflammatory cells. Endothelial cellular signaling that occurs via the family of Rho GTPases coordinates these cell adhesion structures through cytoskeletal remo...
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Insulin is secreted into blood vessels from β cells of pancreatic islets in response to high blood glucose levels. Insulin stimulates an array of physiological responses in target tissues, including liver, skeletal muscle, and adipose tissue, thereby reducing the blood glucose level. Insulin-dependent glucose uptake in skeletal muscle and adipose tissue is primarily mediated by the redistributi...
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Rap1, is required to define the position of the new bud. 1997). In vitro, this interaction is not sufficient to stimulate the GEF activity of Cdc24p, and one functional out-and Molecular Biology University College London come of this interaction in vivo, therefore, is likely to be the localization of Cdc24p to the presumptive bud site London WC1E 6BT United Kingdom (Zheng et al., 1995). In S. p...
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ژورنال
عنوان ژورنال: Cells
سال: 2021
ISSN: 2073-4409
DOI: 10.3390/cells10040915